Author

J. E. Ladbury

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

C.-C. Lin· 6 shared K. M. Suen· 5 shared L. Wieteska· 3 shared Z. Ahmed· 3 shared E. A. Miska· 2 shared A. Akay· 1 shared A. C. Redondo· 1 shared A. F. Odell· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersCell Biology

C.-C. Lin

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer

M. R. Patterson, A. S. Meijers, E. L. Ryder, J. A. Scarth, D. Evans, A. L. Turner, C. W. Wasson, J. E. Darell, C. D. James, M. Wang, J. E. Ladbury, I. M. Morgan, A. Samson, E. L. Morgan, A. Macdonald

This study shows that HPV E7 represses miR-203, leading to LASP1 upregulation and promoting proliferation in HPV-positive cervical cancer.

bioRxiv · Jan 8, 2024Cancer Biology

Expansion microscopy reveals subdomains in C. elegans germ granules

K. M. Suen, T. M. D. Sheard, C.-C. Lin, D. Milonaityte, I. Jayasinghe, J. E. Ladbury

This study uses expansion microscopy to reveal subdomains within C. elegans P granules and their relationship to other germ granules.

bioRxiv · May 29, 2022Cell Biology

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

C.-C. Lin, K. M. Suen, P.-A. Jeffrey, L. Wieteska, A. Stainthorp, C. Seiler, H. Koss, C. Molina-Paris, E. A. Miska, Z. Ahmed, J. E. Ladbury

This study shows that RTKs form liquid-liquid phase-separated states with downstream effectors to enhance signaling fidelity.

Molecular Cell · Mar 1, 2022Peer-reviewedCell Biology

Calcium-binding protein S100A6 interaction with VEGF receptors integrates signaling and trafficking pathways

S. Ponnambalam, L. Bao, G. W. Fearnley, C.-C. Lin, A. F. Odell, A. C. Redondo, G. K. Kinsella, J. B. C. Findlay, J. E. Ladbury, M. Harrison

This study identifies S100A6 as a calcium-dependent regulator of VEGFR trafficking and signaling, integrating these processes in endothelial cell responses to VEGF-A.

bioRxiv · Jul 29, 2021 · PreprintCell Biology

Regulation of kinase activity by combined action of juxtamembrane and C-terminal regions of receptors

C.-C. Lin, L. Wieteska, G. Poncet-Montange, K. M. Suen, S. T. Arold, z. ahmed, J. E. Ladbury

The paper investigates how juxtamembrane and C-terminal regions regulate kinase activity in RTKs, identifying key interactions and mutations linked to disease.

bioRxiv · Oct 1, 2020 · PreprintBiochemistry

Grb2 binding induces phosphorylation-independent activation of Shp2

C.-C. Lin, L. Wieteska, K. M. Suen, A. Kalverda, Z. Ahmed, J. E. Ladbury

This study shows Grb2 binding activates Shp2 independently of phosphorylation, and identifies a peptide that blocks this interaction, reducing Shp2 activity and MAPK signaling.

bioRxiv · Nov 29, 2019Cancer Biology

Direct interaction of PIWI and DEPS-1 is essential for piRNA function and condensate ultrastructure in Caenorhabditis elegans

K. M. Suen, F. Braukmann, R. Butler, D. Bensaddek, A. Akay, C.-C. Lin, N. Doshi, A. Sapetschnig, A. I. Lamond, J. E. Ladbury, E. A. Miska

The paper investigates how PIWI and DEPS-1 interact to support piRNA function and condensate structure in C. elegans.

bioRxiv · Mar 16, 2019 · PreprintCell Biology