Gut microbiota-derived tryptamine impairs insulin sensitivity
L. Zhai, H. Xiao, C. Lin, Y. Y. Lam, H. L. X. Wong, M. Gong, G. Wu, Y. Deng, Z. Ning, C. Huang, Y. Zhang, M. Zhuang, Y. Chao, E. L. Zhang, L. Zhao, , Z.-x. Bian
This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.
bioRxiv · Mar 5, 2022 · PreprintMicrobiology