Y. Y. Lam

APLNR marks a cardiac progenitor derived with human induced pluripotent stem cells

The paper identifies APLNR as a surface marker for cardiac progenitors derived from hiPSCs and shows its utility in isolating and differentiating these progenitors into cardiomyocytes and cardiac mesenchyme.

Saturated cell lysing is critical for high sensitivity microbiome analysis

This study develops a DNA extraction protocol (LPQ) that achieves saturated cell lysis for microbiome analysis, outperforming existing methods in detecting microbial differences.

Two Competing Guilds as a Core Microbiome Signature for Health Recovery

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

Gut microbiota-derived tryptamine impairs insulin sensitivity

This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.

Phenethylamine-producing gut bacteria induces diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis

This study identifies Ruminococcus gnavus as a gut bacterium that contributes to IBS-D by increasing serotonin biosynthesis through phenethylamine production.

A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection.

This study identifies a γδ IEL hyperproliferative phenotype influenced by the intestinal microbiota, which enhances protection against bacterial infection.