Author

E. McSpadden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metagenomics· 2 Research Focus:clustering· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

E. G. Pamer· 3 shared H. Lin· 3 shared A. Rose· 2 shared A. Sundararajan· 2 shared C. Woodson· 2 shared D. Moran· 2 shared J. Little· 2 shared M. McMillin· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

E. G. Pamer

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3 papers

Recent·Most cited

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

Q. Dong, S. Harper, E. McSpadden, S. S. Son, M.-M. Allen, H. Lin, R. C. Smith, C. Metcalfe, V. Burgo, C. Woodson, A. Sundararajan, A. Rose, M. McMillin, D. Moran, J. Little, , E. G. Pamer

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

bioRxiv · May 6, 2024 · PreprintMicrobiology

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution

Z. J. Zhang, C. G. Cole, M. Coyne, H. Lin, N. Dylla, R. C. Smith, E. Waligurski, R. Ramaswamy, C. Woodson, V. Burgo, J. Little, D. Moran, A. Rose, M. McMillin, E. Mcspadden, , L. E. Comstock

The paper characterizes a large collection of Bacteroidales isolates from the human gut, revealing genomic and metabolomic diversity and horizontal gene transfer across species.

bioRxiv · Mar 8, 2024Microbiology

Exposure and resistance to lantibiotics impact microbiota composition and function

Z. J. Zhang, C. Cole, H. Lin, C. Wu, F. Haro, E. McSpadden, W. van der Donk, E. G. Pamer

This study shows that lantibiotic resistance genes in gut bacteria affect microbiota composition and function, with implications for microbiome health and resistance strategies.

bioRxiv · Dec 30, 2023 · PreprintMicrobiology