Author

C. Metcalfe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Sundararajan· 2 shared C. Woodson· 2 shared E. G. Pamer· 2 shared H. Lin· 2 shared L.-C. Fortier· 2 shared M.-M. Allen· 2 shared Q. Dong· 2 shared R. C. Smith· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

A. Sundararajan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

Q. Dong, S. Harper, E. McSpadden, S. S. Son, M.-M. Allen, H. Lin, R. C. Smith, C. Metcalfe, V. Burgo, C. Woodson, A. Sundararajan, A. Rose, M. McMillin, D. Moran, J. Little, , E. G. Pamer

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

bioRxiv · May 6, 2024 · PreprintMicrobiology

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

Q. Dong, H. Lin, M.-M. Allen, J. R. Garneau, J. K. Sia, R. C. Smith, F. Haro, T. McMillen, R. L. Pope, C. Metcalfe, V. Burgo, C. Woodson, N. Dylla, C. Kohout, A. Sundararajan, , E. G. Pamer

This study identifies a 69 base-pair deletion in the cdtR gene that attenuates virulence in ST1 C. difficile strains without affecting colonization.

bioRxiv · Jan 12, 2023Microbiology

Genomic evidence that blind cavefishes are not wrecks of ancient life

M. Policarpo, P. Laurenti, E. Garcia-Machado, C. Metcalfe, S. Retaux, D. Casane

The paper estimates the age of blindness in cavefishes by analyzing decay in eye-specific genes, finding that blindness is relatively recent, ranging from the Early Pliocene to Late Pleistocene.

bioRxiv · Jun 2, 2021 · PreprintEvolutionary Biology