Author

M.-M. Allen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Organism:C. elegans· 1 Assay:proteomics· 1

Frequent Co-Authors

L.-C. Fortier· 3 shared A. Sundararajan· 2 shared C. Metcalfe· 2 shared C. Woodson· 2 shared E. G. Pamer· 2 shared H. Lin· 2 shared J. R. Garneau· 2 shared Q. Dong· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

L.-C. Fortier

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3 papers

Recent·Most cited

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

Q. Dong, S. Harper, E. McSpadden, S. S. Son, M.-M. Allen, H. Lin, R. C. Smith, C. Metcalfe, V. Burgo, C. Woodson, A. Sundararajan, A. Rose, M. McMillin, D. Moran, J. Little, , E. G. Pamer

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

bioRxiv · May 6, 2024 · PreprintMicrobiology

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

Q. Dong, H. Lin, M.-M. Allen, J. R. Garneau, J. K. Sia, R. C. Smith, F. Haro, T. McMillen, R. L. Pope, C. Metcalfe, V. Burgo, C. Woodson, N. Dylla, C. Kohout, A. Sundararajan, , E. G. Pamer

This study identifies a 69 base-pair deletion in the cdtR gene that attenuates virulence in ST1 C. difficile strains without affecting colonization.

bioRxiv · Jan 12, 2023Microbiology

The Clostridioides difficile S-Layer Protein A (SlpA) serves as a general phage receptor

A. L. M. Royer, A. A. Umansky, M.-M. Allen, J. R. Garneau, M. O. Bedoya, J. A. Kirk, G. Govoni, R. P. Fagan, O. Soutourina, L.-C. Fortier

This paper demonstrates that SlpA is a common receptor for multiple C. difficile phages, enabling the rational design of phage cocktails.

bioRxiv · Sep 19, 2022Microbiology