Author

E. G. Pamer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Assay:metagenomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

H. Lin· 5 shared A. Sundararajan· 4 shared Z. J. Zhang· 3 shared C. Woodson· 2 shared C. Wu· 2 shared D. Moran· 2 shared E. Mcspadden· 2 shared E. S. Snitkin· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersMicrobiology

H. Lin

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution

Z. J. Zhang, C. G. Cole, M. Coyne, H. Lin, N. Dylla, R. C. Smith, E. Waligurski, R. Ramaswamy, C. Woodson, V. Burgo, J. Little, D. Moran, A. Rose, M. McMillin, E. Mcspadden, , L. E. Comstock

The paper characterizes a large collection of Bacteroidales isolates from the human gut, revealing genomic and metabolomic diversity and horizontal gene transfer across species.

bioRxiv · Mar 8, 2024Microbiology

Exposure and resistance to lantibiotics impact microbiota composition and function

Z. J. Zhang, C. Cole, H. Lin, C. Wu, F. Haro, E. McSpadden, W. van der Donk, E. G. Pamer

This study shows that lantibiotic resistance genes in gut bacteria affect microbiota composition and function, with implications for microbiome health and resistance strategies.

bioRxiv · Dec 30, 2023 · PreprintMicrobiology

Structure-Activity Relationship Studies of Novel Gut-derived Lantibiotics Against Human Gut Commensals

Z. J. Zhang, C. Wu, D. Dorantes, T. Pappas, A. Sundararajan, H. Lin, E. G. Pamer, W. A. van der Donk

The paper characterizes six gut-derived nisin-like lantibiotics, evaluates their antimicrobial activity against pathogens and commensals, and identifies key residues affecting their activity.

bioRxiv · Sep 15, 2023 · PreprintBioengineering

Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence.

N. T. Q. Nhu, H. Lin, Y. Pigli, J. K. Sia, P. Kuhn, E. S. Snitkin, V. B. Young, M. Kamboj, E. G. Pamer, P. A. Rice, A. Shen, Q. Dong

The paper identifies that longer inverted repeats in the flagellar switch region of C. difficile RT027 strains correlate with greater virulence and phenotypic heterogeneity in flagellar gene expression.

bioRxiv · Jun 22, 2023 · PreprintMicrobiology

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

Q. Dong, H. Lin, M.-M. Allen, J. R. Garneau, J. K. Sia, R. C. Smith, F. Haro, T. McMillen, R. L. Pope, C. Metcalfe, V. Burgo, C. Woodson, N. Dylla, C. Kohout, A. Sundararajan, , E. G. Pamer

This study identifies a 69 base-pair deletion in the cdtR gene that attenuates virulence in ST1 C. difficile strains without affecting colonization.

bioRxiv · Jan 12, 2023Microbiology

Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration

A. S. Little, I. T. Younker, M. S. Schechter, P. Nol Bernardino, R. Meheust, J. Stemczynski, K. Scorza, M. W. Mullowney, D. Sharan, E. Waligurski, R. Smith, R. Ramanswamy, W. Leiter, D. Moran, M. McMillin, , S. H. Light

The paper identifies gut bacteria that use dietary and host-derived metabolites as electron acceptors in anaerobic respiration, revealing new metabolic pathways and reductase evolution.

bioRxiv · Dec 26, 2022Microbiology

The TaxUMAP atlas: efficient display of large clinical microbiome data reveals ecological competition involved in protection against bacteremia

J. Schluter, A. Djukovic, B. P. Taylor, J. Yan, C. Duan, G. A. Hussey, C. Liao, S. Sharma, E. Fontana, L. A. Amoretti, R. J. Wright, A. Dai, J. Peled, Y. Taur, M.-A. Perales, , J. B. Xavier

The paper introduces TaxUMAP, a visualization tool for microbiome data, revealing that Klebsiella species reduce bacteremia risk through competition with other pathogens.

bioRxiv · Sep 27, 2022Microbiology

Monocyte reconstitution and gut microbiota composition after hematopoietic stem cell transplantation

S. Morjaria, A. W. Zhang, S. Kim, J. U. Peled, S. Becattini, E. R. Littmann, E. G. Pamer, M.-A. Perales, M. C. Abt

This study examines the relationship between gut microbiota composition and monocyte recovery after hematopoietic stem cell transplantation, finding no significant association in a small cohort.

Clinical Hematology International · Jan 1, 2020Peer-reviewedImmunology