Author

F. De Smet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Lambrechts· 3 shared S. De Vleeschouwer· 3 shared A. Claeys· 2 shared B. Cole· 2 shared F. M. Bosisio· 2 shared K. L. Ligon· 2 shared M. Derweduwe· 2 shared M. Vanmechelen· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

D. Lambrechts

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

L. van Baarle, V. De Simone, L. Schneider, S. Santhosh, S. Abdurahiman, F. Biscu, R. Schneider, L. Zanoletti, S. Verbandt, Z. Hu, M. Stakenborg, B.-J. Ke, B. Garcia-Reyes, J. Henn, M. Toma, , G. Matteoli

This study identifies IL-1R signaling as a driver of enteric glia-macrophage interactions in colorectal cancer, promoting tumor progression through IL-6 secretion.

bioRxiv · Jun 1, 2023Cancer Biology

Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma

L. Finotto, B. Cole, W. Giese, E. Baumann, A. Claeys, M. Vanmechelen, B. Decraene, M. Derweduwe, N. Dubroja Lakic, G. Shankar, M. Nagathihalli Kantharaju, J. P. Albrecht, I. Geudens, F. Stanchi, K. L. Ligon, , H. Gerhardt

The paper identifies LGALS1 as an immunomodulating target in glioblastoma by analyzing GAM-GBM interactions using single-cell RNA sequencing and zebrafish models.

bioRxiv · Apr 27, 2023 · PreprintCancer Biology

Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma

D. Panovska, P. Nazari, B. Cole, P.-J. Creemers, M. Derweduwe, L. Solie, S. Van Gassen, A. Claeys, T. Verbeke, Y. Saeys, D. Van Der Planken, F. M. Bosisio, E. Put, S. Bamps, P. Clement, , F. De Smet

The paper introduces PROSPERO, a single-cell assay to evaluate therapy response in glioblastoma by measuring molecular drug responses in fresh tumor samples, revealing limited therapeutic capacity and cellular plasticity.

bioRxiv · Oct 17, 2022 · PreprintCancer Biology

Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy

S. Naulaerts, D. M. Borras, A. A. Martinez, J. Messiaen, Y. Van Herck, L. Gelens, T. Venken, I. Vanmeerbeek, S. More, J. Sprooten, O. Bechter, G. Bergers, A. Liston, S. De Vleeschouwer, B. J. Van den Eynde, , A. D. Garg

This study identifies distinct CD8+T cell states in cancer patients using multi-omics data, showing that dysfunctional states resist immunotherapy while exhausted states can be targeted with specific treatments.

bioRxiv · Nov 22, 2021Immunology

The tumor suppressor protein PTEN undergoes amyloid-like aggregation in tumor cells.

F. Claes, E. Maritschnegg, G. De Baets, A. Siekierska, M. Saiz Rubio, M. Ramakers, E. Michiels, F. De Smet, J. Depreeuw, I. Vergote, A. Vanderstichele, A. van den Broeck, S. Olbrecht, E. Hermans, F. Amant, , J. Schymkowitz

This study shows PTEN, a tumor suppressor, undergoes amyloid-like aggregation in tumor cells, both due to mutations and dysregulated protein homeostasis, and links this aggregation to poor clinical outcomes.

bioRxiv · Nov 30, 2020 · PreprintCancer Biology