S. Boeynaems

Arabidopsis thaliana RHAMNOSE 1 condensate formation drives UDP-rhamnose synthesis

The paper shows that RHM1 forms condensates called rhamnosomes, which are essential for UDP-rhamnose synthesis and plant organ development.

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

The paper identifies a common toxic mechanism in positively charged peptides across species and develops a machine learning tool to detect it.

Dynamic mapping of proteome trafficking within and between living cells by TransitID

TransitID maps proteome trafficking between cellular compartments and between cells with nanometer resolution, revealing new roles for stress granules and intercellular signaling.

Poly(A)-binding protein is an ataxin-2 chaperone that emulsifies biomolecular condensates.

The paper identifies a conserved 14aa sequence in ataxin-2 that acts as a condensation switch and reveals poly(A)-binding proteins as RNA-dependent chaperones that regulate this switch.

A modular platform for engineering function ofnatural and synthetic biomolecular condensates

The paper identifies design principles for biomolecular condensates using PopZ and applies them to create synthetic condensates in human cells.

Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress.

This study identifies FLOE1, a prion-like protein in Arabidopsis thaliana, whose hydration-dependent phase separation regulates seed germination under water stress.

Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties

This study shows that spontaneous interactions between proteins and RNA can form multi-layered condensates with distinct material properties and specific amino acid and RNA sequence dependencies.