The mitochondrial Na+/Ca2+ exchanger NCLX is implied in the activation of hypoxia-inducible factors
C. Choya-Foces, P. Hernansanz-Agustin, E. Navarro, M. G. Lopez, J. Egea, A. Martinez-Ruiz
This study shows that NCLX is necessary for HIF-1 stabilization and transcriptional activity during hypoxia, linking acute and medium-term hypoxic responses through mitochondrial signaling.
bioRxiv · Jul 12, 2024Biochemistry