Author

L. Moreno

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Roma· 3 shared J. Sanchez de Toledo· 3 shared M. F. Segura· 3 shared S. Gallego· 3 shared A. Cogolludo· 2 shared G. Pons· 2 shared J. Sansa-Girona· 2 shared L. Garcia-Gilabert· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

J. Roma

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma

G. O. Gallo-Oller, G. Pons, J. Sansa-Girona, N. Navarro, P. Zarzosa, L. Garcia-Gilabert, P. Cabre Fernandez, G. Guillen Barrieza, L. Valero-Arrese, M. F. Segura, J. M. Lizcano, J. Sanchez de Toledo, L. Moreno, S. Gallego, J. Roma

This study shows TRIB3 silencing reduces Akt pathway activity and PAX3-FOXO1 levels in high-risk rhabdomyosarcoma, leading to decreased tumor growth and improved survival.

bioRxiv · Dec 1, 2023Cancer Biology

Vitamin D deficiency induces erectile dysfunction: role of superoxide

M. A. Olivencia, B. Climent, B. Barreira, D. Morales-Cano, A. Sanchez, A. Fernandez, B. Garcia-Gomez, J. Romero-Otero, C. Rodriguez, L. Moreno, D. Prieto, M. J. Larriba, A. Cogolludo, J. Angulo, F. Perez-Vizcaino

This study shows vitamin D deficiency causes erectile dysfunction by increasing superoxide production in penile tissue.

bioRxiv · Aug 9, 2023 · PreprintPharmacology & Toxicology

Analysis of cancer genomic amplifications identifies druggable collateral dependencies within the amplicon

G. Pons, G. Gallo-Oller, N. Navarro, P. Zarzosa, J. Sansa-Girona, L. Garcia-Gilabert, A. Magdaleno, M. F. Segura, J. Sanchez de Toledo, S. Gallego, L. Moreno, J. Roma

The paper identifies druggable collateral dependencies in cancer genomic amplifications using CRISPR/Cas9 screens and integrates gene dependency with druggability and subcellular location data.

bioRxiv · Nov 16, 2022Cancer Biology

Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program

C. Jimenez, R. Antonelli, M. Nadal-Ribelles, L. Devis-Jauregui, P. Latorre, C. Sole, M. Masanas, A. Molero-Valenzuela, A. Soriano, J. Sanchez de Toledo, D. Llobet-Navas, J. Roma, F. Posas, E. de Nadal, S. Gallego, , M. F. Segura

This study shows that disrupting the BAF chromatin remodeller in neuroblastoma cells reduces metastasis by repressing an invasiveness-related epigenomic program.

bioRxiv · May 17, 2022Cancer Biology

Mitochondrial Na+ controls oxidative phosphorylation and hypoxic redox signalling

P. Hernansanz-Agustin, C. Choya-Foces, S. Carregal-Romero, E. Ramos, T. Oliva, T. Villa-Pina, L. Moreno, A. Izquierdo-Alvarez, J. D. Cabrera-Garcia, A. Cortes, A. V. Lechuga-Vieco, P. Jadiya, E. Navarro, E. Parada, A. Palomino-Antolin, , A. Martinez-Ruiz

This study shows that mitochondrial Na+ acts as a second messenger regulating OXPHOS and ROS production through interactions with phospholipids during hypoxia.

bioRxiv · Oct 31, 2019Biochemistry