Author

E. Pellegrino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

M. G. Gutierrez· 3 shared A. Rodgers· 2 shared B. Aylan· 2 shared C. Bussi· 2 shared E. M. Bernard· 2 shared N. Athanasiadi· 2 shared P. Santucci· 2 shared A. Fearns· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

M. G. Gutierrez

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Author profile →

3 papers

Recent·Most cited

LRRK2 kinase dependent and independent function on endolysosomal repair promotes macrophage cell death

R. Morrison, S. R. G. Mihaylov, C. H. Luk, A. Rodgers, N. Athanasiadi, H. Morris, E. Pellegrino, S. K. Ultanir, M. G. Gutierrez

This study identifies LRRK2-G2019S-dependent lysosomal membrane repair defects in macrophages leading to increased cell death.

bioRxiv · Sep 27, 2023 · PreprintCell Biology

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

C. Bussi, T. Heunis, E. Pellegrino, E. M. Bernard, N. Bah, M. Silva Dos Santos, P. Santucci, B. Aylan, A. Rodgers, A. Fearns, J. Mitschke, C. Moore, J. I. MacRae, M. Greco, T. Reinheckel, , M. G. Gutierrez

This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.

bioRxiv · Aug 9, 2022Cell Biology

Visualizing pyrazinamide action by live single cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis

P. Santucci, B. Aylan, L. Botella, E. M. Bernard, C. Bussi, E. Pellegrino, N. Athanasiadi, M. G. Gutierrez

This paper uses live-cell imaging to show that pyrazinamide disrupts Mycobacterium tuberculosis intracellular pH homeostasis, unlike other antibiotics, and that this effect depends on host endolysosomal acidification and PncA activity.

bioRxiv · Dec 20, 2021Microbiology