A. Rodgers

LRRK2 kinase dependent and independent function on endolysosomal repair promotes macrophage cell death

This study identifies LRRK2-G2019S-dependent lysosomal membrane repair defects in macrophages leading to increased cell death.

Nine-residue low-complexity disordered peptide as a model system, an NMR/CD study

The paper characterizes a nine-residue disordered peptide using NMR and CD techniques, concluding it is fully disordered and monomeric in solution.

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.

Solving the Sample Size Problem for Resource Selection Analysis

This paper provides mathematical expressions to determine optimal sample sizes for resource selection analyses, showing that fewer data may be sufficient for strong selection effects.

Correlative Light Electron Ion Microscopy reveal in vivo localisation of bedaquiline in Mycobacterium tuberculosis infected lungs

The paper uses CLEIMiT to show bedaquiline accumulates in specific cell types in M. tuberculosis infected lungs.

The Mycobacterium tuberculosis sRNA F6 modifies expression of essential chaperonins, GroEL2 and GroES

This study identifies the M. tuberculosis sRNA F6 as a regulator of chaperonin expression under starvation conditions, suggesting a role in long-term survival.

Immune profiling of cord blood after prolonged rupture of membranes.

This study identifies transcriptomic changes in cord blood following prolonged rupture of membranes, suggesting immune responses to potential in utero infections.

Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms

The study shows that Mycobacterium tuberculosis does not develop resistance to D-cycloserine due to its ultra-low mutation frequency, not because of a lack of compensatory mechanisms.