Author

P. Santucci

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. G. Gutierrez· 3 shared A. Fearns· 2 shared B. Aylan· 2 shared C. Bussi· 2 shared E. M. Bernard· 2 shared E. Pellegrino· 2 shared A. Rodgers· 1 shared C. Moore· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

M. G. Gutierrez

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

C. Bussi, T. Heunis, E. Pellegrino, E. M. Bernard, N. Bah, M. Silva Dos Santos, P. Santucci, B. Aylan, A. Rodgers, A. Fearns, J. Mitschke, C. Moore, J. I. MacRae, M. Greco, T. Reinheckel, , M. G. Gutierrez

This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.

bioRxiv · Aug 9, 2022Cell Biology

Visualizing pyrazinamide action by live single cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis

P. Santucci, B. Aylan, L. Botella, E. M. Bernard, C. Bussi, E. Pellegrino, N. Athanasiadi, M. G. Gutierrez

This paper uses live-cell imaging to show that pyrazinamide disrupts Mycobacterium tuberculosis intracellular pH homeostasis, unlike other antibiotics, and that this effect depends on host endolysosomal acidification and PncA activity.

bioRxiv · Dec 20, 2021Microbiology

Intracellular localisation of Mycobacterium tuberculosis affects antibiotic efficacy

P. Santucci, D. Greenwood, A. Fearns, K. Chen, H. Jiang, M. G. Gutierrez

This study investigates how the intracellular localization of Mycobacterium tuberculosis affects the efficacy of the antibiotic pyrazinamide (PZA) using multimodal microscopy techniques.

bioRxiv · Nov 25, 2020Microbiology