Author

E. R. Gaunt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Organism:virus· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. Digard· 4 shared C. Sharp· 2 shared F. Grey· 2 shared P. Simmonds· 2 shared B. H. Thompson· 1 shared B. Tesla· 1 shared C. P. Sharp· 1 shared C. R. Dixon· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

P. Digard

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Understanding off-target growth defects introduced to influenza A virus by synonymous recoding

C. P. Sharp, E. H. Thompson, B. Tesla, D. Kurian, P. Simmonds, P. Digard, E. R. Gaunt

This study identifies compensatory mutations that cause replication defects in a CpG-enriched influenza A virus, revealing polymerase slippage and type I interferon induction as key mechanisms.

bioRxiv · Jul 17, 2023 · PreprintMicrobiology

Synthetically engineered IgG1 antibody Fc fragments presenting influenza A virus receptor sialic acid inhibit viral haemagglutination activity, but enhance virus replication in cultured A549 cells

R. J. Pleass, E. R. Gaunt, P. Blundell, C. Vrettou

The paper synthesizes sialylated Fc fragments that inhibit influenza A virus haemagglutination but enhance viral replication in A549 cells, suggesting unintended pro-inflammatory effects.

bioRxiv · Oct 6, 2022 · PreprintImmunology

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy

C. Sharp, B. H. Thompson, T. J. Nash, O. Lee, R. M. Pinto, L. Thorley, Y.-T. Lin, S. Sives, H. Wise, S. M. R. Clohisey, F. Grey, L. Vervelde, P. Simmonds, P. Digard, E. R. Gaunt

This paper engineers an influenza A virus with increased CpG content, showing it is attenuated in mice but replication competent in vaccine propagation systems, suggesting a new strategy for live attenuated vaccines.

bioRxiv · Apr 29, 2022Microbiology

STING Nuclear Partners Contribute to Innate Immune Signalling Responses

C. R. Dixon, P. Malik, J. I. de las Heras, N. Saiz-Ros, F. de Lima Alves, M. Tingey, E. R. Gaunt, C. Richardson, D. Kelly, M. W. Goldberg, G. J. Towers, W. Yang, J. Rappsilber, P. Digard, E. C. Schirmer

The paper identifies nuclear STING partners that contribute to innate immune signaling by interacting with IRF3/7 transcription factors and enhancing antiviral responses.

bioRxiv · Dec 21, 2020Immunology

Intra-genome variability in the dinucleotide composition of SARS-CoV-2

P. Digard, H.-M. Lee, C. Sharp, F. Grey, E. R. Gaunt

The paper analyzes CpG dinucleotide composition in SARS-CoV-2 and other coronaviruses to understand its role in replication and cross-species transmission.

bioRxiv · May 8, 2020Evolutionary Biology