R. M. Pinto

Timing and magnitude of the type-I interferon response are determinants of disease tolerance in arbovirus infection

This study shows that the timing and magnitude of the type-I interferon response determine disease tolerance in bluetongue virus infection between sheep and cattle.

Zoonotic avian influenza viruses evade human BTN3A3 restriction

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy

This paper engineers an influenza A virus with increased CpG content, showing it is attenuated in mice but replication competent in vaccine propagation systems, suggesting a new strategy for live attenuated vaccines.

In vitro evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

This study shows that in vitro evolution of SARS-CoV-2 under remdesivir selects for resistant mutations, but these mutations do not spread widely in global variants.

Segment 2 from influenza A(H1N1)pdm09 viruses confers temperature sensitive HA yield on candidate vaccine virus growth in eggs that is complemented by PB2 701D

This study shows that pdm09 segment 2 in candidate vaccine viruses reduces HA yield in eggs at 37.5°C but this temperature sensitivity is compensated by the PB2 701D mutation, improving HA yield.

Pleotropic effects of mutations in the effector domain of influenza A virus NS1 protein

The paper investigates how mutations in the NS1 protein of influenza A virus affect its ability to promote viral mRNA nuclear export and interacts with cellular factors.