MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression
J. Chen, Q. Zheng, J. L. Hicks, L. Trabzonlu, B. Ozbek, T. Jones, A. Vaghasia, T. C. Larman, R. Wang, M. C. Markowski, S. R. Denmeade, K. J. Pienta, R. H. Hruban, E. S. Antonarakis, A. Gupta, , A. M. De Marzo
The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.
bioRxiv · Feb 20, 2023Cancer Biology