Author

E. Megill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:metabolism & bioenergetics· 3 Assay:metabolomics· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

N. W. Snyder· 6 shared D. Kantner· 3 shared A. Chatoff· 2 shared K. M. Aird· 2 shared M. M. Marcinkiewicz· 2 shared A. Amalric· 1 shared A. Bostwick· 1 shared A. C. Lilly· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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6 shared papersCancer Biology

N. W. Snyder

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production

A. C. Sharrow, E. Megill, A. J. Chen, A. Farooqi, S. McGonigal, N. W. Hempel, N. W. Snyder, R. J. Buckanovich, K. M. Aird

This study shows that ACSS2-mediated acetate conversion to acetyl-CoA promotes quiescence in ovarian cancer cells, linking metabolic reprogramming to therapeutic resistance.

bioRxiv · Jul 12, 2024Cancer Biology

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

A. Uboveja, Z. Huang, R. Buj, A. Amalric, H. Wang, N. K. Tangudu, A. R. Cole, E. Megill, D. Kantner, A. Chatoff, H. Ahmad, M. M. Marcinkiewicz, J. A. Disharoon, S. Graff, E. S. Dahl, , K. M. Aird

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

bioRxiv · Feb 6, 2024Cancer Biology

Lactoylglutathione promotes inflammatory signaling in macrophages

M. N. Trujillo, E. Q. Jennings, E. A. Hoffman, H. Zhang, A. M. Phoebe, G. E. Mastin, N. Kitamura, J. A. Reisz, E. Megill, D. Kantner, M. M. Marcinkiewicz, S. M. Twardy, F. Lebario, E. Chapman, R. L. McCullough, , J. J. Galligan

This study shows that lactoylglutathione (LGSH) promotes inflammatory signaling in macrophages by increasing histone lactoylation and chromatin accessibility.

bioRxiv · Oct 10, 2023 · PreprintBiochemistry

Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

C. Ogier, A. M. Charles Solomon, Z. Lu, L. Recoules, A. Klochkova, L. Gabitova-Cornell, B. Bayarmagnai, D. Restifo, A. Surumbayeva, D. B. Vendramini-Costa, A. Deneka, R. Francescone, A. C. Lilly, A. Sipman, J. C. Gardiner, , I. Astsaturov

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

Comparison of colorimetric, fluorometric, and liquid chromatography-mass spectrometry assays for acetyl-coenzyme A

D. S. Kantner, E. Megill, A. Bostwick, V. Yang, C. Bekeova, A. Van Scoyk, E. Seifert, M. W. Deininger, N. W. Snyder

The paper compares colorimetric, fluorometric, and LC-MS-based assays for measuring acetyl-CoA, finding that LC-MS/MS and LC-HRMS provide reliable results with internal standards, while colorimetric ELISA fails even with standards.

bioRxiv · Jun 1, 2023Biochemistry

Dynamic protein deacetylation is a limited carbon source for acetyl-CoA-dependent metabolism

I. Soaita, E. Megill, D. Kantner, A. Chatoff, Z. Arany, N. W. Snyder, K. E. Wellen, S. W. Trefely

This study shows that dynamic protein deacetylation in Acly-/- MEFs contributes carbons to acetyl-CoA but only transiently supplies about 9% of cellular acetyl-CoA.

bioRxiv · Dec 28, 2022Biochemistry