S. Gan

TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

This paper identifies TRIM32 as an intrinsic restriction factor against alphavirus infection, showing it inhibits viral genome translation through monoubiquitination and that disease mutants lose this antiviral activity.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

Distinct tumor architectures for metastatic colonization of the brain

This study compares the brain metastasis colonization strategies of triple-negative breast cancer and HER2+ breast cancer, revealing distinct tumor architectures and stromal interactions.

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

The paper shows that gut bacteria can survive antibiotic treatment without developing resistance by acquiring mutations that enhance their ability to persist and invade intestinal cells.

Association of gut microbiota with cerebral cortex and cerebrovascular abnormality in human mild traumatic brain injury

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

SARS-COV-2 RBD Oral Vaccine Boosted by Mucosal Immune Adjuvant LTB26 via DCs and B Cells Activation in Mice

This paper develops an oral SARS-COV-2 RBD vaccine using LTB26 adjuvant in mice, showing enhanced antibody production and immune activation through DCs and B cells.

The Quantification of Antibody Elements and Receptors subunit expression using qPCR: The Design of VH, VL, CH, CL, FcR subunits primers for a more holistic view of the immune system.

The paper designs qPCR primers to quantify antibody elements and their receptors in PBMC cDNA, enabling a holistic view of immune system gene expression.