Wee1 opposes APC/C(Cdh1) activity to promote S-phase entry
Luc-Alban Vuillemenot, Lucas G. Morales, Calin-Mihai Dragoi, Betheney R. Pennycook, Edward Harris, Liuyang C. Lin, William A. Weston, Jade-Ellen Brown, Emma Graham, Ivan Andrew, Georgia Roumelioti, Alex Montoya, Laurence Gamé, George R. Young, Pavel V. Shliaha, , Alexis R. Barr
This study identifies a new role for Wee1 in promoting S-phase entry by inhibiting APC/CCdh1, revealing a mechanism that impacts the efficacy and toxicity of Wee1 inhibitors in cancer treatment.
bioRxiv · Dec 2, 2025 · PreprintCell Biology