Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia
Gabriele Guarnaccia, Jimmy Massenet, Alessandra Cecchini, Elena Guarnaccia, Beatrice Silvestri, Chiara Nicoletti, Jesus R Barajas, David Sala, Marcos G. Teneche, Brightany Li, Luca Caputo, Cedomir Stamenkovic, Tatiana M. Moreno, Rabi Murad, Shawn Delaware, , Alessandra Sacco
This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.
bioRxiv · Sep 9, 2026 · PreprintCancer Biology