Author

Beatrice Silvestri

Italian Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:Drosophila· 1

Frequent Co-Authors

Cosimo CommissoiD· 2 shared Yijuan ZhangiD· 2 shared Yu Xin WangiD· 2 shared Alessandra CecchiniiD· 1 shared Alessandra SaccoiD· 1 shared Alessandro RosaiD· 1 shared Alessandro VasciaveoiD· 1 shared Alessio ColantoniiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Cosimo CommissoORCID

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3 papers

Recent·Most cited

Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia

Gabriele Guarnaccia, Jimmy Massenet, Alessandra Cecchini, Elena Guarnaccia, Beatrice Silvestri, Chiara Nicoletti, Jesus R Barajas, David Sala, Marcos G. Teneche, Brightany Li, Luca Caputo, Cedomir Stamenkovic, Tatiana M. Moreno, Rabi Murad, Shawn Delaware, , Alessandra Sacco

This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.

bioRxiv · Sep 9, 2026 · PreprintCancer Biology

Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer

Jennifer L. Hope, Yijuan Zhang, Hannah A. Faso, Evelyn S. Sanchez-Hernández, Beatrice Silvestri, Brianna J. Smith, Sanmati H. Nakil, Sreeja Biswas Roy, Michelle P. Lin, Ashley B. Palete, Swetha Maganti, Lily Ling, Dennis C. Otero, Katelyn T. Byrne, Gabriele Romano, , Linda M. Bradley

This study shows that disabling PSGL-1 enhances anti-tumor immunity in pancreatic cancer by improving CD8+ T cell function and response to PD-1 blockade.

bioRxiv · May 22, 2025 · PreprintImmunology

HuD (ELAVL4) gain-of-function impairs neuromuscular junctions and induces apoptosis in in vitro and in vivo models of amyotrophic lateral sclerosis

Beatrice Silvestri, Michela Mochi, Darilang Mawrie, Valeria de Turris, Alessio Colantoni, Beatrice Borhy, Margherita Medici, Eric Nathaniel Anderson, Maria Giovanna Garone, Christopher Patrick Zammerilla, Udai Bhan Pandey, Alessandro Rosa

This study shows that HuD overexpression impairs neuromuscular junctions and induces apoptosis in ALS models, while its knockdown rescues these defects.

bioRxiv · Aug 22, 2023 · PreprintNeuroscience