Author

Brightany Li

Sanford Burnham Prebys Medical Discovery Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Alessandra SaccoiD· 2 shared Cedomir Stamenkovic· 2 shared Gabriele Guarnaccia· 2 shared Marcos G. TenecheiD· 2 shared Peter D. AdamsiD· 2 shared Aaron P. HavasiD· 1 shared Adarsh RajeshiD· 1 shared Alessandra CecchiniiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Alessandra SaccoORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia

Gabriele Guarnaccia, Jimmy Massenet, Alessandra Cecchini, Elena Guarnaccia, Beatrice Silvestri, Chiara Nicoletti, Jesus R Barajas, David Sala, Marcos G. Teneche, Brightany Li, Luca Caputo, Cedomir Stamenkovic, Tatiana M. Moreno, Rabi Murad, Shawn Delaware, , Alessandra Sacco

This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.

bioRxiv · Sep 9, 2026 · PreprintCancer Biology

Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline

Adarsh Rajesh, Aaron P. Havas, Rouven Arnold, Kathryn Lande, Xue Lei, Kelly Yichen Li, Armin Gandhi, Ana Catarina Franco, Seung‐Hwa Woo, Anthony B. Lagnado, Angela Liou, K. Garrett Evensen, Linshan Laux, Maggie Klaers, Jake Kircher, , Peter D. Adams

This study shows that targeting CCND1-CDK6 reduces DNA damage, inflammation, and age-related decline in mice by suppressing SASP and ISG expression.

Nature Aging · Aug 20, 2026Peer-reviewedCell Biology