Author

Rona D. Yaeger

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-7233-5454Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Aaliyah Washington· 1 shared Alberto VidesiD· 1 shared Alexander I. SpiraiD· 1 shared Alison W. Tisdale· 1 shared Anna Idelevich· 1 shared Antonio Cuevas-NavarroiD· 1 shared Aparna HegdeiD· 1 shared Arvin C. DariD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

Aaliyah Washington

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cooperativity between Ras pathway mutations in colonic tumorigenesis

Christian William Johnson, Anna Idelevich, Bing Shui, Alison W. Tisdale, Eve O’Donoghue, Joshua Cook, Shannon Hull, Moon Hee Yang, Shikha Sheth, Elizabeth M. Terrell, Stefânia Bovo Minto, Deborah K. Morrison, Scott Kopetz, Rona D. Yaeger, Kevin M. Haigis

This study shows that specific KRAS mutations, like A59E, cooperate with other genetic alterations in CRC and affect response to EGFR inhibitors.

bioRxiv · Sep 5, 2025 · PreprintCancer Biology

Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC

Salvador Alonso, Kevan Chu, Marie J. Parsons, Elizabeth Granowsky, Himari Imaya Gunasinghe, Jinru Shia, Rona D. Yaeger, Lukas E. Dow

This study identifies genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC using single-cell spatial transcriptomics and exome sequencing, revealing inflammatory and fetal-like transcriptional signatures associated with resistance.

bioRxiv · Aug 5, 2025 · PreprintCancer Biology

Mechanisms of resistance to active state selective tri-complex RAS inhibitors

Ben Sang, Ling Feng Ye, Feng Hu, Yasin Pourfarjam, Antonio Cuevas-Navarro, Shijie Fan, Zheng Qing Fu, Aaliyah Washington, Diego J. Rodriguez, Alberto Vides, Sumit Kar, Ethan Ahler, Kevin K. Lin, Aparna Hegde, Jacqueline A.M. Smith, , Piro Lito

This study identifies mechanisms of resistance to tri-complex RAS inhibitors in patients with RAS-driven cancers, showing that resistance alterations disrupt the RAS:drug:CYPA tri-complex formation.

bioRxiv · Apr 24, 2025 · PreprintCancer Biology