Author

Emily Souster

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Assay:CRISPR screen· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Aubin RamoniD· 2 shared Biao MaiD· 2 shared Matthew GreenigiD· 2 shared Maurizio MangoliniiD· 2 shared Pietro SormanniiD· 2 shared Rajesh KarattiliD· 2 shared Saket SrivastavaiD· 2 shared Shaun P CordobaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

Aubin RamonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating

Kai Hu, Saket Srivastava, Biao Ma, Yajing Yang, Huimin Wang, Maurizio Mangolini, Jasvinder Kaur Hayre, Emily Souster, Rajesh Karattil, Aubin Ramon, Matthew Greenig, Pietro Sormanni, Shaun P Cordoba, Shimobi C. Onuoha

This paper develops an in vivo CAR T cell platform using lipid nanoparticles and T-trex strategy to enhance safety, efficacy, and tumor control.

bioRxiv · Mar 13, 2026 · PreprintImmunology

Genetic interaction library screening with a next-generation dual guide CRISPR system

Thomas Burgold, Emre Karakoç, Emanuel Gonçalves, Inigo Barrio‐Hernandez, Lisa Dwane, Romina Silva, Emily Souster, Mamta Sharma, Alexandra Beck, Ching Chiek Koh, Lykourgos‐Panagiotis Zalmas, Mathew J. Garnett, Andrew Roger Bassett

The paper introduces a next-generation dual guide CRISPR system for efficient genetic interaction screening, achieving low undesired guide pairs and balanced expression, and demonstrates its application in colorectal cancer cells.

Nature Communications · Dec 6, 2025Peer-reviewedMolecular Biology

Highly potent novel multi-armoured IL13Rα2 CAR-T subverts the immunosuppressive microenvironment of Glioblastoma

Maurizio Mangolini, Saket Srivastava, Emily Souster, Yajing Yang, Huimin Wang, Rajesh Karattil, Liam Schultz, Biao Ma, Diana Pombal, Matthew Greenig, Aubin Ramon, Pietro Sormanni, Shaun P Cordoba, Shimobi C. Onuoha

This paper develops a novel CAR-T cell therapy for glioblastoma that overcomes immunosuppression and improves persistence through a multi-armoured design.

bioRxiv · Jan 10, 2025 · PreprintCancer Biology