Coordinated RNA- and protein-templated synthesis ofdouble-stranded DNA by a dual reverse transcriptase immune system
Megan Wang, Kanta Yoneyama, Rimantė Žedaveinytė, Junichiro Ishikawa, Stephen Tang, Hoang C. Le, Tanner Wiegand, J A Santiago Ramirez, Naoto Nagahata, Yanzhe Ma, Dennis J. Zhang, Erick Helmeczi, Mirela Berisa, Marko Jovanović, Masahiro Hiraizumi, , Samuel H. Sternberg
The paper shows how two reverse transcriptases with different templating strategies work together to produce complementary DNA for antiviral defense.
Cell · Jul 28, 2026Peer-reviewedMicrobiology