Megan Wang

This paper introduces ACE, a method to create genomic chimeras by integrating large genomic segments from donor cells into a recipient genome, demonstrating its ability to generate stable chimeric organisms across species barriers.

The paper shows how two reverse transcriptases with different templating strategies work together to produce complementary DNA for antiviral defense.

The paper identifies DRT10, an antiviral reverse transcriptase, and shows its structural and mechanistic similarities to telomerase, suggesting a bacterial origin for telomerase.

The paper demonstrates that bacterial reverse transcriptases synthesize extrachromosomal genes via rolling-circle amplification to confer antiviral immunity.