Elucidating the Mechanism by Which HIV-1 Nucleocapsid Mutations Confer Resistance to Integrase Strand Transfer Inhibitors
Yuta Hikichi, Ryan C. Burdick, Sean C. Patro, Si-Yuan Ding, Brian T. Luke, Erin Clark, Sherimay D. Ablan, Xiaolin Wu, Vinay K. Pathak, Eric O. Freed
The paper shows HIV-1 NC mutations accelerate viral DNA integration and reduce INSTI sensitivity, acting with IN mutations to confer resistance.
Science Advances · Sep 12, 2025Peer-reviewedMicrobiology