Xiaolin Wu

The paper shows HIV-1 NC mutations accelerate viral DNA integration and reduce INSTI sensitivity, acting with IN mutations to confer resistance.

This study identifies NF1/RASA1/TP53 co-mutations and MEK signaling as key drivers of sinonasal tumorigenesis through in vivo CRISPR screening and drug response testing.

The paper identifies large T-cell clones producing infectious HIV-1 virus as a source of non-suppressible viremia despite ART adherence and no drug resistance.

This paper reports a case of clonal hematopoiesis in a rhesus macaque following lentiviral transduction of HSPC with a strong retroviral promoter, leading to gene overexpression and aberrant splicing.

The paper identifies artefactual fusion DNA sequences produced by blunt-end adapter ligation in PacBio library preparation and recommends an alternative A/T overhang method to reduce them.