Author

Sean C. Patro

Frederick National Laboratory for Cancer ResearchORCID 0000-0001-7550-6047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brian T. LukeiD· 2 shared Adam A. CapoferriiD· 1 shared Eric O. FreediD· 1 shared Erin Clark· 1 shared Gert Uves van ZyliD· 1 shared Jenna M. Hasson· 1 shared Mark Fredric CottoniD· 1 shared Mary F. KearneyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

Brian T. LukeORCID

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2 papers

Recent·Most cited

MicrobiologyScience AdvancesPeer-reviewedSep 12, 2025

Elucidating the Mechanism by Which HIV-1 Nucleocapsid Mutations Confer Resistance to Integrase Strand Transfer Inhibitors

Yuta Hikichi, Ryan C. Burdick, Sean C. Patro…·Eric O. Freed

The paper shows HIV-1 NC mutations accelerate viral DNA integration and reduce INSTI sensitivity, acting with IN mutations to confer resistance.

8 citationstop 3%

humanexperimental assay

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MicrobiologyVirusesPeer-reviewedJul 9, 2025

Differential HIV-1 Proviral Defects in Children vs. Adults on Antiretroviral Therapy

Jenna M. Hasson, Mary Grace Katusiime, Adam A. Capoferri…·Mary F. Kearney

The paper compares HIV-1 proviral defects in children and adults on ART, finding more deletions and defects in children, especially in env and tat regions.

2 citations

humanDNA methylation

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