Author

F. C. Lynn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:mouse· 4 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Organism:human· 2

Frequent Co-Authors

C. Nian· 3 shared D. J. Pasula· 2 shared D. S. Luciani· 2 shared H. Winata· 2 shared J. S. Yoon· 2 shared S. Sasaki· 2 shared B. Hoffman· 1 shared B. Vanderkruk· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersPhysiology

C. Nian

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Author profile →

6 papers

Recent·Most cited

NPAS4 is an allostatic regulator of POMC neuronal activity during diet-induced obesity

J. S. Yoon, D. Gamu, W. T. Gibson, F. C. Lynn

This study shows that Npas4 in POMC neurons regulates food intake during obesity by modulating inhibitory GABA-A receptor expression and neuronal activity.

bioRxiv · Jan 12, 2024 · PreprintPhysiology

Calcium-dependent transcriptional profiles of human pancreatic islet cells reveal functional diversity in islet subpopulations

J. S. Yoon, S. Sasaki, J. Velghe, K. Zosel, M. Y. Y. Lee, H. Winata, C. Nian, F. C. Lynn

The paper profiles calcium-regulated gene expression in human pancreatic islet cells using single-cell RNA sequencing and identifies PCDH7 as a novel beta cell marker with enhanced insulin secretory function.

bioRxiv · Sep 8, 2023 · PreprintPhysiology

Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5 in mice

S. Sasaki, C. Nian, E. E. Xu, D. J. Pasula, H. Winata, S. Grover, D. S. Luciani, F. C. Lynn

This study identifies GRK5 as a regulator of pancreatic β-cell proliferation through phosphorylation of HDAC5, linking it to type 2 diabetes pathogenesis.

iScience · Aug 1, 2023Peer-reviewedPhysiology

Truncated CD19 as a selection marker for the isolation of stem cell derived β-cells

L. T. H. Huang, D. Zhang, C. Nian, F. C. Lynn

This study uses CRISPR/Cas9 to knock-in CD19-mScarlet in hESCs to enrich insulin-expressing SC{beta}-cells through magnetic sorting, improving glucose-stimulated c-peptide secretion.

bioRxiv · Apr 5, 2023Bioengineering

Dynamic Ins2 gene activity defines β-cell maturity states

C. M. J. Chu, H. Modi, S. Skovso, C. Ellis, N. A. J. Krentz, Y. B. Zhao, H. Cen, N. Noursadeghi, E. Panzhinskiy, X. Hu, D. A. Dionne, Y. h. Xia, S. Xuan, M. O. Huising, T. J. Kieffer, , J. Johnson

This study shows that β-cell heterogeneity in insulin production is due to dynamic Ins2 gene activity states, with high activity linked to maturity and reduced viability.

bioRxiv · Jul 18, 2022Cell Biology

Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice

B. Vanderkruk, N. Maeshima, D. J. Pasula, M. An, C. L. McDonald, F. C. Lynn, D. S. Luciani, B. Hoffman

This study shows that H3K4me3 is essential for maintaining beta cell function in adult mice by supporting gene expression for insulin biosynthesis and glucose responsiveness.

bioRxiv · Jan 28, 2021Cell Biology