Author

D. A. Dionne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:mouse· 4 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. Panzhinskiy· 3 shared N. Noursadeghi· 3 shared S. Skovso· 3 shared H. H. Cen· 2 shared H. Modi· 2 shared J. D. Johnson· 2 shared X. Hu· 2 shared A. Bautista· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPhysiology

E. Panzhinskiy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dynamic Ins2 gene activity defines β-cell maturity states

C. M. J. Chu, H. Modi, S. Skovso, C. Ellis, N. A. J. Krentz, Y. B. Zhao, H. Cen, N. Noursadeghi, E. Panzhinskiy, X. Hu, D. A. Dionne, Y. h. Xia, S. Xuan, M. O. Huising, T. J. Kieffer, , J. Johnson

This study shows that β-cell heterogeneity in insulin production is due to dynamic Ins2 gene activity states, with high activity linked to maturity and reduced viability.

bioRxiv · Jul 18, 2022Cell Biology

Parental-fetal interplay of immune genes leads to intrauterine growth restriction

G. Kaur, C. B. M. Porter, O. Ashenberg, J. Lee, S. J. Riesenfeld, M. Hofree, M. Aggelakopoulou, A. Subramanian, S. B. Kuttikkatte, K. E. Attfield, C. A. E. Desel, J. L. Davies, H. G. Evans, I. Avraham-Davidi, L. T. Nguyen, , L. Fugger

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

bioRxiv · Mar 26, 2021Immunology

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition.

E. Panzhinskiy, S. Skovso, H. H. Cen, K. Y. Chu, K. MacDonald, G. Soukhatcheva, D. A. Dionne, L. K. Hallmaier-Wacker, J. S. Wildi, S. Marcil, N. Noursadeghi, F. Taghizadeh, C. B. Verchere, E. Jan, J. D. Johnson

This study shows EIF2A protects pancreatic beta cells from ER stress by rescuing translation inhibition and reducing apoptosis.

bioRxiv · Feb 17, 2021 · PreprintPhysiology

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

S. Skovso, E. Panzhinskiy, J. Kolic, H. H. Cen, D. A. Dionne, X.-Q. Dai, R. B. Sharma, L. Elghazi, C. E. Ellis, K. Faulkner, S. A. M. Marcil, P. Overby, N. Noursadeghi, D. Hutchinson, X. Hu, , J. D. Johnson

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

bioRxiv · Oct 15, 2020Physiology