Author

E. Panzhinskiy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 5 Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

J. D. Johnson· 5 shared S. Skovso· 5 shared H. H. Cen· 4 shared D. A. Dionne· 3 shared J. Kolic· 3 shared N. Noursadeghi· 3 shared P. Overby· 3 shared X. Hu· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersPhysiology

J. D. Johnson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Pharmacological or genetic inhibition of Scn9a protects human and mouse beta cells while dampening insulin secretion in type 1 diabetes

P. Overby, A. G. Gordon, X.-Q. Dai, N. S. Nahirney, S. Provenzano, W. G. Sun, Y. Xia, J. A. Zhang, E. Panzhinskiy, C. M. J. Chu, H. H. Cen, S. Skovso, J. Kolic, A. G. Edwards, P. E. Macdonald, J. D. Johnson

This study shows that inhibiting Scn9a protects beta cells in type 1 diabetes by reducing excitability and improving survival, while also dampening insulin secretion.

bioRxiv · Jun 11, 2023 · PreprintPhysiology

Dynamic Ins2 gene activity defines β-cell maturity states

C. M. J. Chu, H. Modi, S. Skovso, C. Ellis, N. A. J. Krentz, Y. B. Zhao, H. Cen, N. Noursadeghi, E. Panzhinskiy, X. Hu, D. A. Dionne, Y. h. Xia, S. Xuan, M. O. Huising, T. J. Kieffer, , J. Johnson

This study shows that β-cell heterogeneity in insulin production is due to dynamic Ins2 gene activity states, with high activity linked to maturity and reduced viability.

bioRxiv · Jul 18, 2022Cell Biology

Sex differences in islet stress responses support female beta cell resilience

G. P. Brownrigg, Y. H. Xia, C. M. Jamie Chu, S. Wang, C. Chao, J. A. Zhang, S. Skovso, E. Panzhinskiy, X. Hu, J. D. Johnson, E. J. Rideout

This study identifies sex differences in beta cell stress responses, showing female beta cells are more resilient to ER stress in both human and mouse models.

bioRxiv · May 10, 2022 · PreprintCell Biology

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition.

E. Panzhinskiy, S. Skovso, H. H. Cen, K. Y. Chu, K. MacDonald, G. Soukhatcheva, D. A. Dionne, L. K. Hallmaier-Wacker, J. S. Wildi, S. Marcil, N. Noursadeghi, F. Taghizadeh, C. B. Verchere, E. Jan, J. D. Johnson

This study shows EIF2A protects pancreatic beta cells from ER stress by rescuing translation inhibition and reducing apoptosis.

bioRxiv · Feb 17, 2021 · PreprintPhysiology

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

S. Skovso, E. Panzhinskiy, J. Kolic, H. H. Cen, D. A. Dionne, X.-Q. Dai, R. B. Sharma, L. Elghazi, C. E. Ellis, K. Faulkner, S. A. M. Marcil, P. Overby, N. Noursadeghi, D. Hutchinson, X. Hu, , J. D. Johnson

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

bioRxiv · Oct 15, 2020Physiology

Differential effects of voclosporin and tacrolimus on insulin secretion from human islets

J. Kolic, L. Beet, P. Overby, H. H. Cen, E. Panzhinskiy, D. R. Ure, J. L. Cross, R. B. Huizinga, J. D. Johnson

This study compares the effects of voclosporin and tacrolimus on insulin secretion from human islets, finding that tacrolimus impairs insulin secretion while voclosporin does not.

bioRxiv · Apr 30, 2020Cell Biology