Author

C. M. J. Chu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

E. Panzhinskiy· 2 shared S. Skovso· 2 shared A. G. Edwards· 1 shared A. G. Gordon· 1 shared C. Ellis· 1 shared D. A. Dionne· 1 shared F. C. Lynn· 1 shared H. Cen· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPhysiology

E. Panzhinskiy

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Author profile →

2 papers

Recent·Most cited

Pharmacological or genetic inhibition of Scn9a protects human and mouse beta cells while dampening insulin secretion in type 1 diabetes

P. Overby, A. G. Gordon, X.-Q. Dai, N. S. Nahirney, S. Provenzano, W. G. Sun, Y. Xia, J. A. Zhang, E. Panzhinskiy, C. M. J. Chu, H. H. Cen, S. Skovso, J. Kolic, A. G. Edwards, P. E. Macdonald, J. D. Johnson

This study shows that inhibiting Scn9a protects beta cells in type 1 diabetes by reducing excitability and improving survival, while also dampening insulin secretion.

bioRxiv · Jun 11, 2023 · PreprintPhysiology

Dynamic Ins2 gene activity defines β-cell maturity states

C. M. J. Chu, H. Modi, S. Skovso, C. Ellis, N. A. J. Krentz, Y. B. Zhao, H. Cen, N. Noursadeghi, E. Panzhinskiy, X. Hu, D. A. Dionne, Y. h. Xia, S. Xuan, M. O. Huising, T. J. Kieffer, , J. Johnson

This study shows that β-cell heterogeneity in insulin production is due to dynamic Ins2 gene activity states, with high activity linked to maturity and reduced viability.

bioRxiv · Jul 18, 2022Cell Biology