Disrupting peroxisomes alters lipid metabolism in melanoma and uncovers a novel therapeutic vulnerability in combination with MAPK-targeted therapies
F. Huang, F. Cai, M. S. Dahabieh, K. Gunawardena, A. Talebi, J. Dehairs, F. El-Turk, J. Y. Park, C. Goncalves, N. Gagnon, J. Su, P. Gaub, J.-S. Joyal, J. J. Mitchell, J. V. Swinnen, , S. V. del Rincon
This paper identifies a metabolic vulnerability in melanoma cells by disrupting peroxisomes and shows that combining this with MAPK-targeted therapies enhances anti-tumor effects.
bioRxiv · Oct 25, 2022 · PreprintCancer Biology