Author

N. Gagnon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

C. Goncalves· 3 shared F. Huang· 3 shared W. H. Miller· 3 shared J. Su· 2 shared K. K. Mann· 2 shared S. V. del Rincon· 2 shared A. Benoit· 1 shared A. Emond· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

C. Goncalves

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Unveiling the Impact of Arsenic Toxicity on Immune Cells in Atherosclerotic Plaques: Insights from Single-Cell Multi-Omics Profiling.

K. Makhani, X. Yang, F. Dierick, N. Subramaniam, N. Gagnon, T. Ebrahimian, H. Wu, J. Ding, K. K. Mann

This study uses single-cell multi-omics profiling to show arsenic alters macrophage transcription and epigenetics in atherosclerotic plaques, with more profound epigenetic changes.

bioRxiv · Nov 23, 2023 · PreprintPharmacology & Toxicology

Tunable PhenoCycler Imaging of the Murine Pre-Clinical Tumour Microenvironments

M. J. Abraham, C. Goncalves, P. McCallum, V. Gupta, S. E. J. Preston, F. Huang, H. Chou, N. Gagnon, N. A. Johnson, W. H. Miller, K. K. Mann, S. V. del Rincon

This study uses PhenoCycler imaging to analyze the tumor microenvironment in murine cancer models, revealing distinct TME features and cell-cell contact differences across cancer types.

bioRxiv · Sep 18, 2023Cancer Biology

Impact of growth-promoting alternatives on weight gain and gut microbial diversity and activity in piglets

J. Palanee, N. Gagnon, K. Lauzon, S. Methot, M. Blais, G. Talbot, F. Guay, M. Lessard, E. Yergeau, D. Poulin-Laprade

This study evaluates the impact of peri-weaning feeding strategies on gut microbial diversity and activity in piglets, finding limited effects on weight gain but modulatory effects on the microbiota.

bioRxiv · Dec 12, 2022 · PreprintMicrobiology

Disrupting peroxisomes alters lipid metabolism in melanoma and uncovers a novel therapeutic vulnerability in combination with MAPK-targeted therapies

F. Huang, F. Cai, M. S. Dahabieh, K. Gunawardena, A. Talebi, J. Dehairs, F. El-Turk, J. Y. Park, C. Goncalves, N. Gagnon, J. Su, P. Gaub, J.-S. Joyal, J. J. Mitchell, J. V. Swinnen, , S. V. del Rincon

This paper identifies a metabolic vulnerability in melanoma cells by disrupting peroxisomes and shows that combining this with MAPK-targeted therapies enhances anti-tumor effects.

bioRxiv · Oct 25, 2022 · PreprintCancer Biology

The MNK1/2-eIF4E axis contributes to phenotype switching, melanoma progression, and resistance to immunotherapy.

F. Huang, C. Goncalves, M. Bartish, J. Remy-Sarrazin, Q. Guo, A. Emond, W. Yang, D. Plourde, J. Su, M. G. Gimeno, Y. Zhan, M. Attias, A. Galan, T. rzymski, M. Mazan, , S. del Rincon

This study identifies the MNK1/2-eIF4E axis as a driver of melanoma phenotype switching, progression, and immunotherapy resistance, with potential therapeutic targeting.

bioRxiv · May 29, 2020Cancer Biology