Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms
R. C. Schugar, C. M. Gliniak, R. N. Helsley, A. L. Brown, A. Burrows, C. Finney, K. K. Fung, F. M. Allen, D. Ferguson, A. D. Gromovsky, C. Neumann, A. McMillan, J. A. Buffa, J. T. Anderson, M. Mehrabian, , J. M. Brown
The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.
bioRxiv · Dec 4, 2020Physiology