A. Keshavarzian

Integrated multi-cohort analysis of the Parkinson's disease gut metagenome

This study analyzes the gut microbiome in Parkinson's disease across multiple cohorts, identifying consistent taxonomic and functional changes associated with the disease.

A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice

A prebiotic diet reduces motor deficits and microglial activation in α-synuclein overexpressing mice by altering gut microbiota and microglial states.

Markers of Fungal Translocation Are Elevated During Post-Acute Sequelae of SARS-CoV-2 Infection and Induce NF-κB Triggered Inflammation.

This study identifies elevated fungal translocation markers in PASC patients, which induce NF-κB inflammation through Dectin-1 signaling.

Colon epithelial cell-specific Bmal1 deletion impairs bone formation in mice

This study shows that deleting Bmal1 in colon epithelial cells reduces trabecular and cortical bone in male mice, but not females.

COVID-19 Severity Is Associated with Differential Antibody Fc-mediated Innate Immune Functions

The paper examines how differences in antibody-mediated innate immune functions correlate with COVID-19 severity.

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.

Genetic and Immunological Evidence for Microbial Transfer Between the International Space Station and an Astronaut

The paper tracks microbial transfer between an astronaut and the ISS environment, identifies specific taxa, and shows immune system adaptation.

Gut bacterial deamination of residual levodopa medication for Parkinson's disease

This study shows that gut bacteria deaminate levodopa, a Parkinson's disease medication, and identifies the enzyme responsible, with implications for drug effectiveness and side effects.