Author

A. J. Lusis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Physiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

A. L. Brown· 2 shared C. Pan· 2 shared J. M. Brown· 2 shared M. Mehrabian· 2 shared A. Alvarsson· 1 shared A. Burrows· 1 shared A. Centzone· 1 shared A. D. Gromovsky· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. L. Brown

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Gut bacteria impact host uric acid burden and its association with atherosclerosis

K. Kasahara, R. L. Kerby, Q. Zhang, M. Pradhan, M. Mehrabian, A. J. Lusis, G. Bergstrom, F. Backhed, F. E. Rey

This study shows gut bacteria influence uric acid levels and atherosclerosis in mice and humans by catabolizing purines.

bioRxiv · Dec 12, 2022 · PreprintMicrobiology

Membrane-Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose Homeostasis

W. Massey, V. Varadharajan, R. Banerjee, A. L. Brown, A. J. Horak, R. C. Hohe, E. R. Chan, C. Pan, R. Zhang, D. S. Allende, A. J. Lusis, J. M. Brown

This study shows that MBOAT7 in adipocytes regulates PI homeostasis and contributes to hyperinsulinemia and systemic insulin resistance in mice.

bioRxiv · May 19, 2022 · PreprintBiochemistry

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

R. C. Schugar, C. M. Gliniak, R. N. Helsley, A. L. Brown, A. Burrows, C. Finney, K. K. Fung, F. M. Allen, D. Ferguson, A. D. Gromovsky, C. Neumann, A. McMillan, J. A. Buffa, J. T. Anderson, M. Mehrabian, , J. M. Brown

The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.

bioRxiv · Dec 4, 2020Physiology

Mammary ductal epithelium controls cold-induced adipocyte thermogenesis

L. C. Santos, D. Arneson, A. Alvarsson, K. Chella Krishnan, A. Centzone, S. Patel, S. Sadeh, I. S. Ahn, G. Diamante, I. Cely, A. J. Butte, C. Blanpain, S. A. Stanley, A. J. Lusis, X. Yang, P. Rajbhandari

The paper shows that mammary ductal epithelial cells regulate cold-induced adipocyte thermogenesis via secreted factors called mammokines in female mice.

bioRxiv · Nov 14, 2020 · PreprintCell Biology

Machine learning reveals time-varying microbial predictors with complex effects on glucose regulation

O. Aasmets, K. Lüll, J. M. Lang, C. Pan, J. Kuusisto, K. Fischer, M. Laakso, A. J. Lusis, E. Org

This study uses machine learning to identify gut microbiome predictors of glucose regulation and T2D risk using longitudinal data from a Finnish cohort.

bioRxiv · Aug 13, 2020Microbiology

The Lands cycle modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle

P. J. Ferrara, X. Rong, J. A. Maschek, A. R. Verkerke, P. Siripoksup, H. Song, K. C. Krishnan, J. M. Johnson, J. Turk, J. A. Houmard, A. J. Lusis, J. E. Cox, S. R. Shaikh, P. Tontonoz, K. Funai

The study identifies LPCAT3 as a key regulator of plasma membrane lipid organization and insulin sensitivity in skeletal muscle, showing its role in modulating lipid metabolism and insulin action.

bioRxiv · Dec 23, 2019 · PreprintPhysiology