tRNA modifications tune decoding of codon pairs to prevent cellular quality control responses
Jie Wu, Cristián Eggers, Olga Sin, L. Koziej, Héctor Mancilla, Fabienne Mollet, Hans Robert Schöler, Hannes C. A. Drexler, Tristan Ranff, Christian Fufezan, Claudine Kraft, Sebastian Glatt, Jan M. Bruder, Sebastian A. Leidel
This study shows that tRNA modifications affect codon pair decoding, leading to ribosome stalling and triggering quality control responses to prevent protein aggregation.
Nucleic Acids Research · Nov 5, 2025Peer-reviewedBiochemistry