Sebastian Glatt

This paper identifies the EF-hand domain of MINDY3 as a ubiquitin and RAD23 UBL-binding domain, revealing its role in DNA damage response regulation.

The paper uses solid-state nanopore sensing to analyze conformational changes in a mutated tRNAArgUCU associated with neurodegeneration.

This study shows that tRNA modifications affect codon pair decoding, leading to ribosome stalling and triggering quality control responses to prevent protein aggregation.

This study shows that tRNA thiolation defects in humans cause proteostasis and tissue homeostasis issues, but mice with similar defects develop normally.

The paper shows that Pus7 mutations reduce tRNA-Asp levels, activating the integrated stress response and glycolytic reprogramming, which contributes to aggressive behavior.

This paper demonstrates an encapsidic production method for degradation-prone polypeptides using engineered protein cages, enabling their microbial production and isolation.

The paper reveals a new role of the Gal80 N-terminus in Gal4p activation by mediating nuclear import and interaction with KlGal1p.