Synergistic effects of deleting the tyrosine phosphatases Shp1 and Shp2 on megakaryopoiesis and thrombopoiesis in mice
Elsa Barré, Marc‐Damien Lourenco‐Rodrigues, Lucie Zimmermann, Marion Pugliano, Cécile Loubière, Fabienne Proamer, Jean‐Yves Rinckel, Anita E. Eckly, Zihan Qu, Jinmin Miao, Zhong‐Yin Zhang, Yotis A. Senis, Alexandra Mazharian
This study shows that deleting Shp1 and Shp2 in mice impairs megakaryopoiesis and thrombopoiesis, leading to macrothrombocytopenia and reduced platelet function.
bioRxiv · Oct 24, 2025 · PreprintCell Biology