Renaud Poincloux

The paper uses cryo-electron tomography and computational methods to infer the assembly states of actin networks in podosomes, revealing layered helical order and preferred orientation transitions.

This study uses dual human lung models to evaluate anti-tuberculosis drugs and host-directed therapies, revealing compartment-specific efficacy and immune responses.

This study shows that inhibiting glycolysis in TB-infected macrophages reduces HIV-1 spread by blocking tunneling nanotubes and Siglec-1 expression.

This study identifies moesin's role in osteoclast fusion and function, showing its impact on bone resorption and disease therapy.

The paper introduces 4polar3D, a method for 3D orientation imaging of dense actin networks using ratiometric polarization splitting, demonstrating its ability to resolve nanoscale organization in cellular structures.

This study identifies Myo1e and Myo1f as regulators of podosome dynamics and macrophage migration by localizing to the podosome base.

The paper identifies a TUBB3+ cell population in TB granulomas across multiple species and patients, distinct from known cell types and present in other infections.

This study shows that the hypervirulent Klebsiella pneumoniae capsule masks O-antigen, preventing neutrophil recognition and killing, while O-antigen can also trigger neutrophil degranulation and NET formation.

This paper identifies a three-dimensional extracellular matrix cage formed by laminin and collagen IV that anchors megakaryocytes in the bone marrow and regulates their maturation and intravasation.