Zihan Qu

AI-enabled discovery of small molecules targeting complementary pathways for hair follicle rejuvenation

This study uses AI to discover small molecules that rejuvenate hair follicles by targeting complementary pathways, showing increased cell viability and suppression of follicular miniaturization.

Synergistic effects of deleting the tyrosine phosphatases Shp1 and Shp2 on megakaryopoiesis and thrombopoiesis in mice

This study shows that deleting Shp1 and Shp2 in mice impairs megakaryopoiesis and thrombopoiesis, leading to macrothrombocytopenia and reduced platelet function.

Development of high-affinity, single-domain protein binders for neutralizing household allergens

This study develops and characterizes AVA, single-domain protein binders that neutralize major household allergens from cats, dogs, and dust mites.

Discovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG

The paper identifies D2HG and L2HG-induced O-2-hydroxyglutarylation with chiral specificity, revealing inhibitory effects on kinases MRCKA and SLK.

Correlative Imaging for Comprehensive Molecular Mapping of Individual Cell Types in Biological Tissues

This paper introduces a correlative imaging method using nano-DESI MSI to map lipids, metabolites, peptides, and proteins in single tissue sections, revealing molecular gradients in mouse pancreatic tissue.