Perforin-mediated pore formation at the lytic synapse triggers the canonical pyroptotic cell death pathway
Brienne McKenzie, Marie-Pierre Puisségur, Lucie Demeersseman, Frecia Rodriguez, Emma Cini, Ashwin Jainarayanan, Marcus A. Widdess, Claire C. Staton, Lina Chen, Vincent Sibaud, Laurence Lamant, Michael Loran Dustin, Agathe Bernand, Sabina Müller, Salvatore Valitutti
This study shows perforin triggers pyroptosis in target cells by activating the NLRP3/caspase-1/gasdermin D pathway, while sustained CTL interaction leads to apoptosis.
bioRxiv · May 24, 2024 · PreprintCell Biology