Author

Brienne McKenzie

InsermORCID 0000-0001-6829-9828Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Lucie DemeerssemaniD· 2 shared Marie-Pierre PuisséguriD· 2 shared Michael Loran DustiniD· 2 shared Sabina MülleriD· 2 shared Salvatore ValituttiiD· 2 shared Agathe Bernand· 1 shared Ashwin JainarayananiD· 1 shared Claire C. StatoniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Lucie DemeerssemanORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 5, 2025

Stenocytosis: a mechanism for supramolecular attack particle transfer at the CTL lytic synapse

Lucie Demeersseman, Claudia Schirra, Ute Becherer…·Salvatore Valitutti

The paper describes stenocytosis, a mechanism by which CTLs transfer supramolecular attack particles into target cells through narrow actin gaps.

DOI 10.1101/2025.11.05.686769

𝕏 PostBluesky

Cell BiologybioRxivPreprintMay 24, 2024

Perforin-mediated pore formation at the lytic synapse triggers the canonical pyroptotic cell death pathway

Brienne McKenzie, Marie-Pierre Puisségur, Lucie Demeersseman…·Salvatore Valitutti

This study shows perforin triggers pyroptosis in target cells by activating the NLRP3/caspase-1/gasdermin D pathway, while sustained CTL interaction leads to apoptosis.

1 citation

experimental assayhost-pathogen & immune response

𝕏 PostBluesky