Author

G. A. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Bolomsky· 1 shared A. Huet· 1 shared A. M. Stults· 1 shared A. P. Wiita· 1 shared B. C. Hann· 1 shared B. Haupl· 1 shared B. T. Aftab· 1 shared C. E. Pegg· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Bolomsky

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

Y. Yang, T. Oellerich, P. Chen, A. Bolomsky, M. Ceribelli, B. Haupl, G. W. Wright, J. D. Phelan, D. W. Huang, J. W. Lord, C. K. Van Winkle, X. Yu, J. Wisnieski, J. Q. Wang, F. A. Tosto, , R. M. Young

This study identifies how oncogenic RAS activates mTORC1 in multiple myeloma by co-opting amino acid sensing pathways through a novel signaling complex.

bioRxiv · Nov 28, 2021Cancer Biology

The herpes simplex virus type I deamidase enhances propagation but is dispensable for retrograde axonal transport into the nervous system

A. M. Stults, G. A. Smith

The paper investigates the role of HSV-1 pUL37 deamidase in neuroinvasion, finding it enhances propagation but is not required for retrograde axonal transport.

bioRxiv · Jul 16, 2019Microbiology

The apical region of the herpes simplex virus major capsid protein promotes capsid maturation

L. L. Ruhge, A. Huet, J. F. Conway, G. A. Smith

This study investigates the role of the VP5 apical region in herpes simplex virus capsid maturation and finds that mutations in this region delay viral propagation and induce procapsid accumulations.

bioRxiv · May 11, 2018Microbiology

Dissecting the herpesvirus architecture by targeted proteolysis

G. R. Daniel, C. E. Pegg, G. A. Smith

This study uses targeted proteolysis to determine the binding sites of tegument proteins to the herpesvirus capsid, revealing that pUL36 is stably anchored at its carboxyl terminus.

bioRxiv · May 1, 2018Microbiology

Repurposing Tofacitinib As An Anti-Myeloma Therapeutic To Reverse Growth-Promoting Effects Of The Bone Marrow Microenvironment

C. Lam, M. Murnane, H. Liu, G. A. Smith, S. Wong, J. Taunton, J. O. Liu, C. S. Mitsiades, B. C. Hann, B. T. Aftab, A. P. Wiita

This paper validates tofacitinib as an effective anti-myeloma therapy by reversing bone marrow microenvironment-driven growth signals in vitro and in vivo.

bioRxiv · May 28, 2017Cancer Biology