G. C. Sparagna

Genetic evidence for functional diversification of gram-negative intermembrane phospholipid transporters

This study investigates the functional differences between YhdP and TamB in phospholipid transport in E. coli, revealing differential substrate preferences and roles in maintaining membrane composition under cold stress.

Altered Cardiolipin Metabolism is Associated with Cardiac Mitochondrial Dysfunction in Pulmonary Vascular Remodeled Perinatal Rat Pups

This study examines phospholipid metabolism in perinatal rat pups with pulmonary vascular remodeling, finding altered cardiolipin and phosphatidylethanolamine levels linked to mitochondrial dysfunction and cardiac dysfunction.

Tafazzin deficiency in mouse mesenchymal stem cells potentiates their immunosuppression and impairs activated B lymphocyte immune function

This study shows that Tafazzin deficiency in mouse mesenchymal stem cells enhances their immunosuppressive effects on activated B lymphocytes.

Reduced protein kinase C delta association with a higher molecular weight complex in mitochondria of Barth Syndrome lymphoblasts

The paper examines reduced PKCδ association with a higher molecular weight complex in mitochondria of Barth Syndrome lymphoblasts, linking it to impaired mitochondrial function.

The Cardiolipin Transacylase Tafazzin Regulates Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets from Mice

This study shows that Tafazzin deficiency in pancreatic islets reduces insulin secretion and mitochondrial function under low-glucose conditions.

Berberine alleviates adiposity and cardiac dysfunction in offspring exposed to gestational diabetes mellitus

This study shows that berberine treatment reduces adiposity and improves cardiac and pancreatic function in offspring exposed to gestational diabetes mellitus.

Maturation of human induced pluripotent stem cell-derived cardiomyocytes for modeling hypertrophic cardiomyopathy

This study develops a method to mature hiPSC-CMs, enabling them to model adult-onset cardiovascular disease like hypertrophic cardiomyopathy.