Author

B. P. Kellman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

N. E. Lewis· 3 shared Y. Zhang· 3 shared C. Martino· 2 shared D. R. Sandoval· 2 shared J. D. Esko· 2 shared T. M. Clausen· 2 shared A. B. Ward· 1 shared A. D. Swafford· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

N. E. Lewis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

T. M. Clausen, D. R. Sandoval, C. B. Spliid, J. Pihl, C. D. Painter, B. E. Thacker, C. A. Glass, A. Narayanan, S. A. Majowicz, Y. Zhang, J. L. Torres, G. J. Golden, R. Porell, A. F. Garretson, L. Laubach, , J. D. Esko

This study shows SARS-CoV-2 spike protein binds to heparan sulfate and ACE2 on cells codependently, forming a complex that facilitates infection, suggesting potential therapeutic targets.

Cell · Nov 1, 2020Peer-reviewedMicrobiology

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

C. Martino, B. P. Kellman, D. R. Sandoval, T. M. Clausen, C. A. Marotz, S. J. Song, S. Wandro, L. S. Zaramela, R. A. Salido Benitez, Q. Zhu, E. Armingol, Y. Vazquez-Baeza, D. McDonald, J. T. Sorrentino, B. Taylor, , R. Knight

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.

bioRxiv · Aug 17, 2020 · PreprintMicrobiology

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

P. Zhao, J. L. Praissman, O. C. Grant, Y. Cai, T. Xiao, K. E. Rosenbalm, K. Aoki, B. P. Kellman, R. Bridger, D. H. Barouch, M. A. Brindley, N. E. Lewis, M. Tiemeyer, B. Chen, R. J. Woods, L. Wells

The paper characterizes glycosylation of SARS-CoV-2 Spike and ACE2 using glycomics and simulations to understand their interactions and guide immunogen design.

bioRxiv · Jun 25, 2020Biochemistry

Combating viral contaminants in CHO cells by engineering STAT1 mediated innate immunity

A. W. T. Chiang, S. Li, B. P. Kellman, G. Chattopadhyay, Y. Zhang, C.-C. Kuo, J. M. Gutierrez, F. Ghazi, H. Schmeisser, P. Menard, S. Petersen Bjorn, B. G. Voldborg, A. S. Rosenberg, M. Puig, N. E. Lewis

The paper identifies Gfi1 and Trim24 as repressors of STAT1 in CHO cells and shows that knocking them out increases resistance to RNA viruses.

bioRxiv · Sep 21, 2018Bioengineering