J. M. Gutierrez

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

Contrasting Patterns of Pierce's Disease Risk in European Vineyards Under Global Warming

This study assesses future Pierce's Disease risk in European vineyards under global warming, identifying a +3°C temperature threshold for expanded spread beyond Mediterranean regions.

Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL

VIDAL is a machine-learning tool that automatically analyzes dermonecrosis in mouse models to assess antivenom efficacy, offering an accurate and reproducible alternative to manual methods.

Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms

This paper describes the discovery of a broadly-neutralizing human antibody effective against multiple snake venoms, demonstrating its therapeutic potential in mice.

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

The paper shows repurposed drugs and their combinations reduce cytotoxicity of snake venoms in cell and mouse models, offering potential new treatments for snakebite envenoming.

High efficacy of therapeutic equine hyperimmune antibodies against SARS CoV-2 variants of concern

This study demonstrates that therapeutic equine polyclonal antibodies effectively neutralize SARS-CoV-2 variants of concern.

Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

This paper develops and pre-clinically evaluates two equine-derived anti-SARS-CoV-2 polyclonal formulations for potential COVID-19 treatment, showing high neutralizing capacity against SARS-CoV-2 infection.

Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras

This study shows that three spitting cobra lineages independently evolved venom with increased pain-enhancing toxins, likely in response to hominin emergence.

Multiplex secretome engineering enhances recombinant protein production and purity

This study shows that deleting multiple host cell proteins in CHO cells improves recombinant protein production and purity through enhanced purification efficiency.

Deficient skeletal muscle regeneration after injury induced by a Clostridium perfringens strain associated with gas gangrene

This study investigates muscle regeneration impairment after C. perfringens-induced myonecrosis in mice, identifying vascular damage, cytokine imbalance, and fibrosis as key factors.

Combating viral contaminants in CHO cells by engineering STAT1 mediated innate immunity

The paper identifies Gfi1 and Trim24 as repressors of STAT1 in CHO cells and shows that knocking them out increases resistance to RNA viruses.